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Your Guide to Navigating Supplements During Perimenopause

I get asked about supplements a LOT. And the truth of it is through twenty years of trial and error combined with ten years of functional medicine training and application I have arrived at a combo that is perfect for me. No one’s diet is perfect 24/7, 365 days so a backup plan is essential to being proactive about your own health and wellness. Just promise me you won’t go buy a bunch of RANDO supplements on Amazon or GNC! It’s really worth your time to reach out to a functional health practitioner to get the EXACT targeted nutraceutical support you need.

A Disclaimer About Supplements

Supplements are intended to “supplement” – but I think some of us are still stuck in old patterns of belief that “a pill will solve the problem.” Wherever you are in your health, working on a challenge or maintaining the right place for you, take note that your adrenal glands return to a state of homeostasis (balance) a lot faster if you manage your life stress consistently. If meditation doesn’t work for you, try breath work. If getting to the gym is unrealistic, go for a walk, and if you can’t bear the thought of a yoga class, grab a notebook and start a gratitude journal. Any one act that will change your physiology for just ten minutes a day is RESTORATIVE. I talk a LOT about different supplements, nutraceuticals, adaptogens and essential oils that assist the body in healing adrenal gland dysfunction to educate (and hopefully add value to you). But, at the end of the day, supplements are tricky and meant to supplement a current protocol that a health practitioner has designed for you. I talk about supplements A LOT. So how do you know which ones are right for you? Test rather than guess the root causes of your health issues!! Perimenopause (and your hormones during perimenopause) is complex. Guessing which supplements to take might even exacerbate symptoms!

Understanding Supplement Regulations

First, remember supplements aren’t regulated by the FDA like medications. So the safety, efficacy, and quality of supplements can vary widely. Where you purchase them matters! Manufacturers are responsible for ensuring their products are safe (but they don’t always do this) and accurately labeled, but there’s limited oversight to verify any claims. 

  • Look for products that have been independently tested by reputable organizations. NSF International or ConsumerLab are two to check out.
  • In the absence of stringent FDA oversight, knowledge is power. Research supplement brands, read reviews and ask your doc!
  • Just because a product is available doesn’t mean it’s safe or appropriate for YOU.

Before taking a new supplement, always consult your doctor, preferably a functional medicine one! 

Not All Supplements Are Created Equal

When it comes to supplements, quality matters. Not all supplements are created equal, and the difference in quality can significantly impact their effectiveness and your experience. Some products may contain fillers, artificial ingredients, or lower-quality forms of nutrients that are less bioavailable, meaning your body cannot fully absorb and utilize them.

  • First, check for third-party testing and certification on the label, which indicates that the product has undergone independent quality checks.
  • Research the brand’s reputation and customer reviews to gauge the experiences of other users. Brands that are transparent about their sourcing and manufacturing processes are more reliable choices.
  • Consider supplement form. Some nutrients, like certain vitamins and minerals, have different forms with varying levels of bioavailability. Opt for supplements that use highly bioavailable forms for maximum absorption and effectiveness. 

Cycling Supplements

Some supplements, particularly adaptogens, require cycling to maintain their effectiveness and prevent reliance. Adaptogens are natural substances that help the body adapt to stress and restore balance. Cycling means you take the supp for a specific amount of time, then give your body a break before resuming use. You don’t want to develop a tolerance! Plus, you want the adaptogen to keep its efficacy. For example, you might take an adaptogen for four weeks, followed by a one-week break before starting again.

The Importance of Bioavailability

Ever heard of bioavailability? It plays a crucial role in the effectiveness of supplements. It refers to the proportion of a nutrient that your body can absorb and utilize. Even the most potent supplement may be ineffective if it has low bioavailability, as your body may not be able to access the nutrients inside. To enhance bioavailability:

  • Choose supplements that use high-quality, easily absorbed forms of nutrients. For example, look for methylated forms of B vitamins or chelated minerals, which tend to have higher absorption rates.
  • Some supplements benefit from being taken with food or other nutrients that aid absorption. Check your manufacturer’s directions.

I hope this helps! Remember to TEST and not GUESS the root cause of your symptoms to find supplements that work for YOU. If you know what supplements YOU need, check out my dispensary.


The information provided in this blog post is for informational purposes only. The information is a result of years of practice and experience by Dr. Francesca LeBlanc. However, this information is NOT intended as a substitute for the advice provided by your physician. Do not use the information provided in this post for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or homeopathic supplement, or using any treatment for a health problem. Please, do not disregard professional medical advice or delay in seeking professional advice because of something you have read on this website.

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5 Non-Negotiable Supplements Every Woman in Perimenopause Should Know About

Perimenopause is not for the faint of heart. The hormone shifts, the brain fog, the restless nights, and the “why does my body feel like it’s rebelling against me?” moments can leave you frustrated and searching for answers. The truth is, while lifestyle foundations like nutrition, movement, and sleep will always be step one, smart supplementation can make the ride a whole lot smoother.

I’m not talking about throwing spaghetti at the wall with trendy powders or gimmicky “menopause miracle” products. I’m talking about research-backed supplements that support mood, energy, hormones, and long-term health during one of the most critical phases of a woman’s life. These are the ones I consider non-negotiables — the baseline tools every perimenopausal woman should at least know about.

And spoiler: all of these are currently featured in my shop because I like to keep it stupid simple (KISS). 

1. Creatine: Not Just for Gym Bros

Let’s clear this up once and for all: creatine is not just for bodybuilders. Yes, it supports muscle strength and recovery but its benefits go way beyond the squat rack.

In fact, a 2021 study showed that women who added creatine to their lifestyle interventions saw depressive symptoms improve faster than lifestyle changes alone (PMID: 33800439). That’s huge. Perimenopause is often marked by mood changes thanks to shifting hormones, and creatine seems to play a role in brain energy metabolism that can help steady the ship.

So while creatine can help you feel stronger in the gym, it may also help you feel stronger mentally and emotionally. That’s why I use it and recommend it regularly.

My pick: Kleen Athlete Creatine

2. Magnesium: The Mineral of Calm

If there were one mineral I could beam into every perimenopausal woman’s body, it would be magnesium. Your hormones, nervous system, and circadian rhythm absolutely crave it. Research shows magnesium can lower stress (PMID: 28526383), support hormone balance (PMID: 23056605), and improve sleep quality. Translation? Better recovery, deeper rest, and fewer “I might lose it” moments.

Here’s the problem: most women are deficient. Between stress, processed foods, and soil depletion, magnesium intake is often far below optimal. Adding a high-quality magnesium supplement can be a game-changer for mood, energy, and sleep.

My pick: Ortho Molecular Reacted Magnesium

3. Protein: Your Metabolism’s Best Friend

Say it with me: protein is not optional. Perimenopause is often when women start noticing changes in body composition — slower metabolism, easier weight gain, harder recovery. One reason is declining muscle mass, and protein is your defense against it.

Did you know that even a simple protein shake before a meal can naturally boost your GLP1 levels (PMID: 23666746)? That means better satiety, steadier blood sugar, and fewer energy crashes. In a world of ultra-processed convenience foods, protein gives your body the building blocks it needs to thrive.

Whether you’re blending it into a smoothie, stirring it into oatmeal, or just shaking it up with water, a high-quality protein powder is one of the easiest tools for perimenopausal health.

My pick: Ballerina Farm Farmer Protein

4. Omega-3: Nature’s Inflammation Fighters

If I could describe Omega-3 fatty acids in one phrase, it would be cellular peacekeepers. EPA and DHA (the active compounds in Omega-3 supplements) are inflammation fighters that support brain, heart, and hormonal health.

Research shows Omega-3s can improve insulin sensitivity and reduce systemic inflammation (PMID: 29538286). That’s crucial because perimenopause is often a time when women start experiencing creeping blood sugar issues, higher cholesterol, or increased cardiovascular risk. Think of Omega-3s as long-term health insurance in a capsule, one of the smartest daily investments you can make.

My pick: Nordic Naturals Pro-Omega 2000

5. Nicotinamide Riboside: The Longevity Edge

Finally, let’s talk about one of the most exciting emerging supplements: Nicotinamide Riboside (NR). It’s been called a “longevity vitamin” because of its ability to boost NAD+ levels, which decline with age.

Why does this matter? NAD+ is a coenzyme involved in energy production, DNA repair, and cellular resilience. Early research suggests boosting NAD+ through NR supplementation may improve energy, slow aspects of aging, and support longevity (PMID: 37630330). Is the science still evolving? Absolutely. But the early signals are strong enough that I consider this a valuable addition to the perimenopause toolkit.

My pick: Tru Niagen Pro 500

Why These Are My Non-Negotiables

Each of these supplements fills a unique gap in perimenopausal health. Together, they create a foundation for:

  • Stable energy and mood
  • Better sleep and stress resilience
  • Muscle preservation and metabolic support
  • Reduced inflammation and long-term protection
  • A proactive approach to aging and longevity

They’re not gimmicks. They’re not “quick fixes.” They’re tools that, when combined with nutrition, movement, and lifestyle changes, can help you feel like yourself again — maybe even better. So if perimenopause has you feeling like your body is running the show, take this as your sign.